|
Date Generale Personal
Centru Echipamente |
|
PROTOCOL NO. 462.1-2-17/19
TITLE OF THE GRANT: The effect of proton beam irradiation on the in vitro action of antitumor drugs
THEME: 04-2-1132-2017/2019
YEAR: 2017
LABORATORY IN JINR: Dzelepov Laboratory of uclear Problems (DLNP)
PARTNERS IN ROMANIA: Faculty of Physics, University of Bucharest (FFUB)
RESPONSIBLE PERSONS: Lect. dr. Claudia CHILOM (FFUB), Gennady V. MYTSIN (DLNP)
OBJECTIVES:
- the study of the interaction between bio-mimetic membranes and antitumor drugs irradiated with proton beams accelerated in the Phasotron DLNP, at JINR;
- in vitro testing of antitumor drugs (exposed or unexposed to proton beams) - hemolytic activities;
- in vitro testing of antitumor drugs (exposed or unexposed to hadrons) cytotoxic effects.
EXPECTED RESULTS:
Main results expected from this investigation are:
- the spectroscopic characterization of the interaction between bio-mimetic membranes and antitumor drugs irradiated with proton beam.
- the investigation of the hemolytic activity by in vitro testing of antitumor drugs (exposed or unexposed to proton beam)
- the investigation of the cytotoxic effects by in vitro testing of antitumor drugs (exposed or unexposed to hadrons).
|